Lessons from 54 years of pharmaceutical research

Ten lessons from 15 years of transgenic Populus research

The goal of this paper is to describe the diverse kinds of research and interactions with the private and public sectors we have had while creating and field-testing many different kinds of transgenic poplars (genus Populus, aspens and cottonwoods) over the last ~15 years. [We use ‘transgenic’ to refer to any trees produced using asexual gene transfer, regardless of the origin of the genes.] Ou...

Twenty years of immunocontraceptive research: lessons learned.

The National Wildlife Research Center (NWRC) began immunocontraception vaccine research by testing porcine zona pellucida (PZP) on white-tailed deer (Odocoileus virginianus). Early PZP research demonstrated that PZP induced infertility; however, increased length of the rut was observed in PZP-treated deer. An alternative vaccine using a keyhole limpet hemocyanin-gonadotropin-releasing hormone (...

Biophysical highlights from 54 years of macromolecular crystallography.

The United Nations has declared 2014 the International Year of Crystallography, and in commemoration, this review features a selection of 54 notable macromolecular crystal structures that have illuminated the field of biophysics in the 54 years since the first excitement of the myoglobin and hemoglobin structures in 1960. Chronological by publication of the earliest solved structure, each illus...

Lessons from 50 Years of Uvulopalatopharyngoplasty

Commentary Although the surgical treatment of Obstructive Sleep Apnea (OSAS) expanded significantly over the last years with different techniques, uvulopalatopharyngoplasty (UPPP) remains the most common procedure used in the treatment of this complex syndrome. It dates back to 50 years ago when Ikematsu [1] in Japan, developed a surgical procedure to relieve snoring shortening the soft palate ...

Lessons from Three Years of Inspection Data